Co-ordinated regulation of translation following DNA damage
نویسندگان
چکیده
منابع مشابه
Optimal Co-ordinated Control of Hydropower Plants
River hydropower plants must accomplish several tasks. They have to generate electric energy, guarantee the navigation and reduce the extent of a flood if possible. If there is a cascade of hydropower stations in a river, then it is not possible to solve these tasks with a decentralized control strategy optimally. One is faced with a multiple criteria optimization problem. This contribution pre...
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Increases in p53 protein levels after DNA damage have largely been attributed to an increase in the half-life of p53 protein. Here we demonstrate that increased translation of p53 mRNA is also a critical step in the induction of p53 protein in irradiated cells. Ribosomal protein L26 (RPL26) and nucleolin were found to bind to the 5' untranslated region (UTR) of p53 mRNA and to control p53 trans...
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Genome integrity relies on precise coordination between DNA replication and chromosome segregation. Whereas replication stress attracted much attention, the consequences of mitotic perturbations for genome integrity are less understood. Here, we knockdown 47 validated mitotic regulators to show that a broad spectrum of mitotic errors correlates with increased DNA breakage in daughter cells. Une...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.19.9467